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当前位置: 首页 > 产品中心 > peptide > BD Biosciences/APC Mouse Anti-Human CD117/5 μL/341096
商品详细BD Biosciences/APC Mouse Anti-Human CD117/5 μL/341096
BD Biosciences/APC Mouse Anti-Human CD117/5 μL/341096
BD Biosciences/APC Mouse Anti-Human CD117/5 μL/341096
商品编号: 341096
品牌: bdbiosciences
市场价: ¥11658.57
美元价: 6662.04
产地: 美国(厂家直采)
公司:
产品分类: 多肽合成
公司分类: peptide
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Product DetailsRecommended AssayReferences

Description

CD117, clone 104D2, is derived from fusion of Sp2/0 myeloma cells with splenocytes from BALB/c mice immunized with the megakaryoctic cell line MOLM-1.

CD117 binds to the receptor for stem cell factor (SCF). It selectively recognizes NIH-3T3 cells transfected with human c-kit, the gene that codes for SCF-R. CD117 antibody does not block the epitope that binds SCF.

Preparation and Storage

The PE conjugate is supplied as 10 µg in 1.0 mL (10 µg/mL) of phosphate-buffered saline (PBS). The PerCP-Cy5.5 conjugate is supplied as 1 µg in 1.0 mL (1 µg/mL) of PBS. The PE-Cy7 conjugate is supplied as 6.25 µg in 0.5 mL (12.5 µg/mL) of PBS. The APC conjugate is supplied as 5 µg in 0.5 mL (10 µg/mL) of PBS. PBS contains gelatin and 0.1% sodium azide.

Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.

  1. Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline—Third Edition. Wayne, PA: Clinical and Laboratory Standards Institute; 2005. CLSI document M29-A3.

  2. Ashman LK, Cambareri A, Nguyen L, Bühring H-J. CD117 workshop panel report. In: Kishimoto T, Kikutani H, von dem Borne AEGK, et al, eds. Leucocyte Typing VI: White Cell Differentiation Antigens. New York, NY: Garland Publishing, Inc; 1997:816-818.

  3. Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT. Functional isolation and characterization of human hematopoietic stem cells. Science. 1995;267:104-108.

  4. Briddell RA, Broudy VC, Bruno E, Brandt JE, Srou EF, Hoffman R. Further phenotypic characterization and isolation of human hematopoietic progenitor cells using a monoclonal antibody to the c-kit receptor. Blood. 1992;79:3159-3167.

  5. Broudy VC, Lin N, Zsebo KM, et al. Isolation and characterization of a monoclonal antibody that recognizes the human c-kit receptor. Blood. 1992;79:338-346.

  6. Centers for Disease Control. Perspectives in disease prevention and health promotion update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in health-care settings. MMWR.1988;37:377-388.

  7. Deberry C, Mou S, Linnekin D. Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem J. 1997;327 73-80.

  8. Gunji Y, Nakamura M, Osawa H, et al. Human primitive hematopoietic progenitor cells are more enriched in KITlow cells than in KIThigh cells Blood. 1993;82:3283-3289.

  9. Hashimoto K, Matsumura I, Tsujimura T, et al. Necessity of tyrosine 719 and phosphatidylinositol 3"-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine kinase with the Asp814Val mutation. Blood. 2003;101:1094-1102.

  10. Ikuta K, Weissman IL. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci USA. 1992;89:1502-1506.

  11. Kinashi T, Springer TA. Steel factor and c-kit regulate cell-matrix adhesion. Blood. 1994;83:1033-1038.

  12. Maddens S, Charruyer A, Plo I, et al. Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule. Blood. 1991;78:1706-1712.

  13. Meininger CJ, Yano H, Rottapel R, Bernstein A, Zsebo KM, Zetter BR. The c-kit receptor ligand functions as a mast cell chemoattractant. Blood. 1992;79:958-963.

  14. Nocka K, Buck J, Levi E, Besmer P. Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors. EMBO J. 1990;9:3287-3294

  15. Nocka K, Majumder S, Chabot B, et al. Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice—evidence for an impaired c-kit kinase in mutant mice. Genes Dev. 1989;3:816-826.

  16. Olweus J, Terstappen LWMM, Thompson PA, Lund-Johansen F. Kit signaling inhibits the sphingomyelin-ceramide pathway through PLCγ1: implication in stem cell factor radioprotective effect. Blood. 2002;100:1294-1301.

  17. Ratajczak MZ, Luger SM, DeRiel K, Abrahm J, Calabretta B, Gewirtz AM. Role of the KIT protooncogene in normal and malignant human hamatopoiesis. Proc Natl Acad Sci USA. 1992;89:1710-1714

  18. Samayawardhena LA, Kapur R, Craig AW. Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells. Blood. 2007;109:3679-3686.

  19. Simmons P, Aylett G, Niutta S, To L, Juttner C, Ashman L. c-kit is expressed by primitive human hematopoietic cells that give rise to colony-forming cells in stroma-dependent or cytokinesupplemented culture. Exp Hematol. 1994;22:157-165.

  20. Ueda S, Mizuki M, Ikeda H, et al. Ueda S, Mizuki M, Ikeda H, et al. Blood. 2002;99:3342-3349.

  21. Zola H, Swart B, Nicholson I, Voss E. Leukocyte and Stromal Cell Molecules: The CD Markers. Hoboken, NJ: John Wiley & Sons, Inc.; 2007.

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