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当前位置： 首页 > 产品中心 > peptide > BD Biosciences/Purified Mouse Anti-Human TCRγ/δ/20 μL/347900
商品详细BD Biosciences/Purified Mouse Anti-Human TCRγ/δ/20 μL/347900
BD Biosciences/Purified Mouse Anti-Human TCRγ/δ/20 μL/347900
BD Biosciences/Purified Mouse Anti-Human TCRγ/δ/20 μL/347900
商品编号： 347900
品牌： bdbiosciences
市场价： ¥0.00
美元价： 0.00
产地： 美国(厂家直采)
公司：
产品分类： 多肽合成
公司分类： peptide
联系Q Q： 3392242852
电话号码： 4000-520-616
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Description

The Anti–TCRγ/δ-1 antibody, clone 11F2, is derived from hybridization of mouse Sp2/0 myeloma cells with spleen cells from BALB/c mice immunized with a Sepharose® bead/CD3/γ/δ TCR complex. Anti–TCRγ/δ-1 is mitogenic for γ/δ-TCR–bearing T lymphocytes.

The Anti–TCRγ/δ-1 antibody reacts with a framework epitope of the γ/δ T-cell antigen receptor (TCR). The γ/δ TCR is a heterodimeric glycoprotein that is noncovalently associated with the CD3 antigen. The γ and δ TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. The γ chain forms either disulfide-linked or non–disulfide-linked heterodimers with the δ-subunit.

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  • FormatPurified
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Preparation and Storage

Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.

  1. Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline—Third Edition. Wayne, PA: Clinical and Laboratory Standards Institute; 2005. CLSI document M29-A3.

  2. Blink SE, Miller SD. The contribution of gammadelta T cells to the pathogenesis of EAE and MS. Curr Mol Med. 2009;9:15-22.

  3. Bonneville M, O"Brien RL, Born WK. Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat Rev Immunol. 2010;10:467-478.

  4. Borst J, van Dongen J, Bolhuis R, et al. Distinct molecular forms of human T cell receptor γ/δ detected on viable T cells by a monoclonal antibody. J Exp Med. 1988;167:1625-1644.

  5. Cairo C, Hebbeler AM, Propp N, Bryant JL, Colizzi V, Pauza CD. Innate-like gammadelta T cell responses to mycobacterium Bacille Calmette-Guerin using the public V gamma 2 repertoire in Macaca fascicularis. Tuberculosis (Edinb). 2007;87:373-383.

  6. Carding SR, Egan PJ. The importance of gamma delta T cells in the resolution of pathogen-induced inflammatory immune responses. Immunol Rev. 2000;173:98-108.

  7. Centers for Disease Control. Perspectives in disease prevention and health promotion update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in health-care settings. MMWR. 1988;37:377-388.

  8. Chen ZW. Immune regulation of gammadelta T cell responses in mycobacterial infections. Clin Immunol. 2005;116:202-207.

  9. Garcia VE, Sieling PA, Gong J, et al. Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens. J Immunol. 1997;159:1328-1335

  10. Huang D, Chen CY, Zhang M, et al. Clonal immune responses of Mycobacterium-specific gammadelta T cells in tuberculous and non-tuberculous tissues during M. tuberculosis infection. PLoS One. 2012;7:e30631.

  11. Lanier LL, Federspiel N, Ruitenberg JJ, et al. The T-cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes: A CD3-associated disulfide-linked γ chain heterodimer. J Exp Med. 1987;165:1076-1094.

  12. Lanier LL, Ruitenberg JJ, Bolhuis RL, Borst J, Phillips JH, Testi R. Structural and serological heterogeneity of γ/δ T cell antigen receptor expression in thymus and peripheral blood. Eur J Immunol. 1988;18:1985-1992.

  13. Lanier LL, Serafini AT, Ruitenberg JJ, et al. The gamma T-cell antigen receptor. J Clin Immunol. 1987;7:429-440.

  14. Testi R, Lanier LL. Functional expression of CD28 on T cell antigen receptor gamma/delta-bearing T lymphocytes. Eur J Immunol. 1989;19:185-188.

  15. Urban EM, Chapoval AI, Pauza CD. Repertoire development and the control of cytotoxic/effector function in human gammadelta T cells. Clin Dev Immunol. 2010;2010:732893.

  16. Voogt PJ, Falkenburg JH, Fibbe WE, et al. Normal hematopoietic progenitor cells and malignant lymphohematopoietic cells show different susceptibility to direct cell-mediated MHC-non-restricted lysis by T cell receptor-/CD3- , T cell receptor γ/δ+/CD3+ and T cell receptor-α/β+/CD3+ lymphocytes. J Immunol. 1989;142:1774-1780.

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公司介绍
BD是世界上最大的生产和销售医疗设备、医疗系统和试剂的医疗技术公司之一。致力于提高全世界人类的健康水平。BD专注于改进药物治疗，提高传染性疾病诊断的质量和速度，推进新型药物和疫苗的研究与发现。BD公司具有强大的研发能力和世界上最棘手的多种疾病进行斗争的能力。公司于1897年在纽约成立，总部位于美国新泽西州的富兰克林湖，业务遍及全球。公司的业务可分为BD医疗、BD诊断、BD生物科学三大类，生产销售包
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