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当前位置: 首页 > 产品中心 > peptide > BD Biosciences/纯化小鼠抗人CD8/20μL/346310
商品详细BD Biosciences/纯化小鼠抗人CD8/20μL/346310
BD Biosciences/纯化小鼠抗人CD8/20μL/346310
BD Biosciences/纯化小鼠抗人CD8/20μL/346310
商品编号: 346310
品牌: bdbiosciences
市场价: ¥12461.40
美元价: 7120.80
产地: 美国(厂家直采)
公司:
产品分类: 多肽合成
公司分类: peptide
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Product DetailsRecommended AssayReferences

Description

CD8 clone SK1 is derived from hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with human peripheral blood T lymphocytes.

The CD8 antibody recognizes the 32-kilodalton (kDa) α-subunit of a disulfide-linked bimolecular complex. The majority of peripheral blood CD8+ T lymphocytesexpress an α/β heterodimer (Mr 32, 30 kDa), while CD8+CD16+ natural killer (NK)lymphocytes and CD8+ T-cell receptor (TCR)-γ/δ+ T lymphocytes express an α/α homodimer (Mr 30 kDa). CD8+TCR-α/β+ T lymphocytes can express either an α/α homodimer or α/β heterodimer. The CD8 antigenic determinant binds to class I major histocompatibility (MHC) molecules, resulting in increased adhesion between the CD8+ T lymphocytes and target cells. Binding of the CD8 antigen to class I MHC molecules enhances the activation of resting T lymphocytes. The CD8 antigen is coupled to a protein tyrosine kinase, p56lck. The CD8:p56lck complex can play a role in T-lymphocyte activation through mediation of the interactions between the CD8 antigen and the CD3/TCR complex.

Preparation and Storage

Store vials at 2°C to 8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.

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